Efemp2^tm1.2Tynk
Targeted Allele Detail

Summary

• Symbol: Efemp2^tm1.2Tynk
• Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 2; targeted mutation 1.2, Tomoyuki Nakamura
• MGI ID: MGI:4410302
• Synonyms: Fbln4^deltaEx2
• Gene: Efemp2 Location: Chr19:5523982-5532545 bp, + strand Genetic Position: Chr19, 4.33 cM, cytoband A
• Alliance: Efemp2^tm1.2Tynk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154659
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removes exon 2. The absence of protein expression was confirmed by western blot analysis on lung extracts. (J:154659)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efemp2 Mutation: 26 strains or lines available

References

• Original: J:154659 Horiguchi M, et al., Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19029-34
• All: 1 reference(s)