Tg(Ins1-cre/ERT)1Lphi
Transgene Detail

Summary

• Symbol: Tg(Ins1-cre/ERT)1Lphi
• Name: transgene insertion 1, Louis Philipson
• MGI ID: MGI:4410453
• Synonyms: MIP-CreER, MIP-Cre/ERT, MIP-CreERT^1Lphi
• Transgene: Tg(Ins1-cre/ERT)1Lphi Location: unknown
• Alliance: Tg(Ins1-cre/ERT)1Lphi page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Ins1-cre/ERT)1Lphi expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ins1 (MGI:96572)

• Mutation details: An 8.3 kb fragment of the mouse insulin promoter (Ins1; from nucleotide -8280 to +12 relative to the transcriptional start site) drives cDNA encoding cre recombinase fused to the mutated mouse estrogen receptor ligand-binding domain. A 2.1 kb fragment of the hGH gene was added to function as a transcriptional stop signal. The 12.5 kb construct was purified and microinjected into fertilized pronuclei of CD1 mice. Line 1 was established. (J:169727)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ins1 (mouse) Summary of all recombinase alleles driven by Ins1. Comparative matrix view of recombinase activities Alliance mouse Ins1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:169727 Wicksteed B, et al., Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes. 2010 Dec;59(12):3090-8
• All: 100 reference(s)