Rnf103^tm1.1Thg
Targeted Allele Detail

Summary

• Symbol: Rnf103^tm1.1Thg
• Name: ring finger protein 103; targeted mutation 1.1, Tamotsu Hashimoto-Gotoh
• MGI ID: MGI:4410507
• Synonyms: kf-1^-
• Gene: Rnf103 Location: Chr6:71470878-71487865 bp, + strand Genetic Position: Chr6, 32.16 cM
• Alliance: Rnf103^tm1.1Thg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154853
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector contains a diphtheria toxin cassette, a neo cassette in reverse orientation inserted 3' to exon 4 and loxP sites flanking the neo cassette and exon 4. Exon 4 includes coding sequences for the transmembrane regions, the ubiquitination site and zinc finger binding domain. Mice were crossed with mice carrying Tg(CAG-cre)12Miya to remove exon 4 and the neo cassette leaving a single loxP site downstream of exon 3. Protein was not detectable by Western blot and immunochemistry analyses. (J:154853)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rnf103 Mutation: 30 strains or lines available

References

• Original: J:154853 Tsujimura A, et al., Mice Lacking the kf-1 Gene Exhibit Increased Anxiety- but not Despair-Like Behavior. Front Behav Neurosci. 2008;2:4
• All: 3 reference(s)