Tg(tetO-ATXN3)2904Olri
Transgene Detail

Summary

• Symbol: Tg(tetO-ATXN3)2904Olri
• Name: transgene insertion 2904, Olaf Riess
• MGI ID: MGI:4410556
• Synonyms: MJD77
• Transgene: Tg(tetO-ATXN3)2904Olri Location: unknown
• Alliance: Tg(tetO-ATXN3)2904Olri page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-ATXN3)2904Olri expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN3 (4287)

  Atxn3

  (MGI:1099442)

• Mutation details: The tetracycline response element was used to drive inducible expression of the human gene with 77 CAG repeats. Five lines were created (lines 2909, 2776, 2285, 2904, and 2723) with different transgene copy numbers and CAG repeats. Line 2904 contains three copies of the transgene with 60, 65, and 80 CAG repeats per copy. This line also exhibits the highest level of protein expression. (J:154079)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:154079 Boy J, et al., Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3. Hum Mol Genet. 2009 Nov 15;18(22):4282-95
• All: 4 reference(s)