Del(15Krt7-Krt18)1Tmm
Targeted Allele Detail
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Symbol: |
Del(15Krt7-Krt18)1Tmm |
Name: |
deletion, Chr 15, Thomas M Magin 1 |
MGI ID: |
MGI:4410584 |
Synonyms: |
Del(15Krt80-Krt18)1Tmm, KtyII- |
Gene: |
Del(15Krt7-Krt18)1Tmm Location: Chr15:101246196-101940461 bp Genetic Position: Chr15, Syntenic
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Del(15Krt7-Krt18)1Tmm/Del(15Krt7-Krt18)1Tmm embryos exhibit severe growth retardation and apoptosis
Show the 2 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutations: |
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Insertion, Intergenic deletion, Intragenic deletion
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Del(15Krt7-Krt18)1Tmm involves 34 genes/genome features (Mir1941, Gm671, Krt7 ...)
View all
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Mutation details: LoxP sites were inserted 5' and 3' of the keratin type II gene cluster, encompassing 0.68 Mb, 26 type II genes and 1 keratin type I gene (Krt18). Cre mediated recombination deleted the entire cluster leaving a single loxP site flanked by 3' and 5' hprt mini-genes and the the tyrosinase (Tyr) and agouti (A) coat color genes. The absence of the transcripts and gene products was confirmed by RT-PCR and immunofluorescence microscopy in homozygous embryos. Due to the absence of all type II keratins, all the type I keratins were sensitive to proteolysis, so homozygous mice lack all 54 keratin proteins. ES cells carrying Krt1ctm1Tmm and Igs11tm1Tmm and were used to create this deletion.
(J:153804)
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Generation of the Del(15Krt7-Krt18)1Tmm deletion |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Del(15Krt7-Krt18)1Tmm Mutation: |
0 strains or lines available
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Original: |
J:153804 Vijayaraj P, et al., Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor. J Cell Biol. 2009 Oct 19;187(2):175-84 |
All: |
6 reference(s) |
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