Tg(HBB-AR-HBA2,-HBB*)58Rub
Transgene Detail

Summary

• Symbol: Tg(HBB-AR-HBA2,-HBB*)58Rub
• Name: transgene insertion 58, Edward M Rubin
• MGI ID: MGI:4411997
• Synonyms: alphabeta^{S Antilles}
• Transgene: Tg(HBB-AR-HBA2,-HBB*)58Rub Location: unknown
• Alliance: Tg(HBB-AR-HBA2,-HBB*)58Rub page

Transgene origin

• Strain of Origin: Swiss Webster

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(HBB-AR-HBA2,-HBB*)58Rub expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBA2 (3040)

  Hba-a1	(MGI:96015)
  Hba-a2	(MGI:96016)

• Mutation details: The 800 bp DNA fragment containing the hypersensitive II region of the human HBB locus control region was used to drive erythroid-specific expression of human HBA2 and human HBB containing the Sickle Antilles mutations (G6V and V23I) in co-injected constructs. Two founders were generated (14 and 58). The line from founder 58 contains 4 copies of the HBA2 expressing construct and 10 copies of the HBB* expressing construct. (J:136653)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:136653 Rubin EM, et al., Hypoxia-induced in vivo sickling of transgenic mouse red cells. J Clin Invest. 1991 Feb;87(2):639-47
• All: 6 reference(s)