Pla2g6^m1J
Spontaneous Allele Detail

Summary

• Symbol: Pla2g6^m1J
• Name: phospholipase A2, group VI; mutation 1, Jackson
• MGI ID: MGI:4412026
• Gene: Pla2g6 Location: Chr15:79170428-79212590 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Pla2g6^m1J page

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Viral insertion
• Mutation details: A viral insertion occurred spontaneously in intron 1 upstream of the start codon, resulting in a dramatic reduction of transcript levels. (J:183152)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Pla2g6 Mutation: 66 strains or lines available

References

• Original: J:183152 Strokin M, et al., Severe disturbance in the Ca2+ signaling in astrocytes from mouse models of human infantile neuroaxonal dystrophy with mutated Pla2g6. Hum Mol Genet. 2012 Jun 15;21(12):2807-14
• All: 3 reference(s)