Zfp24^hmcns
Spontaneous Allele Detail

Summary

• Symbol: Zfp24^hmcns
• Name: zinc finger protein 24; hypomyelinated central nervous system
• MGI ID: MGI:4412036
• Gene: Zfp24 Location: Chr18:24142759-24153867 bp, - strand Genetic Position: Chr18, 12.55 cM, cytoband B1
• Alliance: Zfp24^hmcns page

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: A spontaneous mutation with an A insertion in a stretch of four As, coding nucleotides 586-589, resulting in a frame-shift and premature stop codon, eliminating 155 amino acids including the zinc finger domain. (J:156938)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zfp24 Mutation: 23 strains or lines available

References

• Original: J:156938 Howng SY, et al., ZFP191 is required by oligodendrocytes for CNS myelination. Genes Dev. 2010 Feb 1;24(3):301-11
• All: 1 reference(s)