Fzd4^tm2.1Nat
Targeted Allele Detail

Summary

• Symbol: Fzd4^tm2.1Nat
• Name: frizzled class receptor 4; targeted mutation 2.1, Jeremy Nathans
• MGI ID: MGI:4412057
• Synonyms: Fz4^CKOAP
• Gene: Fzd4 Location: Chr7:89053574-89062341 bp, + strand Genetic Position: Chr7, 49.32 cM
• Alliance: Fzd4^tm2.1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154020
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP site was inserted in the 5' UTR and another was inserted 3' of the 3' UTR. An alkaline phosphatase sequence was inserted 3' of the last loxP site and was followed by an frt flanked PGK-neo cassette. Flp recombinase expression resulted in the excision of the PGK-neo cassette. (J:154020)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fzd4 Mutation: 31 strains or lines available

References

• Original: J:154020 Ye X, et al., Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell. 2009 Oct 16;139(2):285-98
• All: 9 reference(s)