Tg(SNCA*A30P)2Nbm
Transgene Detail

Summary

• Symbol: Tg(SNCA*A30P)2Nbm
• Name: transgene insertion 2, Robert L Nussbaum
• MGI ID: MGI:4412059
• Synonyms: PAC-Tg(SNCA^A30P) line 2
• Transgene: Tg(SNCA*A30P)2Nbm Location: unknown
• Alliance: Tg(SNCA*A30P)2Nbm page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SNCA*A30P)2Nbm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: To generate the PAC-Tg(SNCAA30P) transgene, the 146 kb RPCI-1 human male P1 artificial chromosome (PAC) clone 27M07, containing the entire human SNCA (synuclein, alpha (non A4 component of amyloid precursor)) gene and 34 kb of its upstream region, was modified to have the A30P human mutation associated with autosomal dominant Parkinson's disease. This transgene was microinjected into the pronuclei of fertilized FVB/N ova. The transgene inserted onto a somatic chromosome. (J:154971, J:156741)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:156741 Kuo YM, et al., Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. Hum Mol Genet. 2010 May 1;19(9):1633-50
• All: 3 reference(s)