Gsx2^tm2.1Kc
Targeted Allele Detail

Summary

• Symbol: Gsx2^tm2.1Kc
• Name: GS homeobox 2; targeted mutation 2.1, Kenneth Campbell
• MGI ID: MGI:4412065
• Synonyms: Gsx2^flox
• Gene: Gsx2 Location: Chr5:75236262-75238554 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Gsx2^tm2.1Kc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154936
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Germ line, flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:154936)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsx2 Mutation: 18 strains or lines available

References

• Original: J:154936 Waclaw RR, et al., Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates. Neuron. 2009 Aug 27;63(4):451-65
• All: 6 reference(s)