Mpp1^tm1Ahc
Targeted Allele Detail

Summary

• Symbol: Mpp1^tm1Ahc
• Name: membrane protein, palmitoylated; targeted mutation 1, Athar H Chishti
• MGI ID: MGI:4412070
• Gene: Mpp1 Location: ChrX:74153339-74174622 bp, - strand Genetic Position: ChrX, 38.15 cM
• Alliance: Mpp1^tm1Ahc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154749
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 7-11 encoding the 4.1-binding domain (D5) and the guanylate kinase-like (GUK) domain were replaced with a neo cassette via homologous recombination. Absence of protein expression was confirmed by western blot analysis of erythrocytes from homozygous mice. (J:154749)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mpp1 Mutation: 11 strains or lines available

References

• Original: J:154749 Quinn BJ, et al., Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19842-7
• All: 1 reference(s)