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Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Targeted Allele Detail
Summary
Symbol: Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Name: intergenic site 1; targeted mutation 2, Jeremy Nathans
MGI ID: MGI:4412094
Synonyms: Iis1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat, Ubbtm2Nat, Z/Norrin
Gene: Igs1  Location: unknown  Genetic Position: Chr11, Syntenic
Alliance: Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154020
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA site 5' of the Ubb gene was targeted with a construct composed of a CMV/beta-actin enhancer and promoter (CAG), a floxed beta-geo with three transcription termination sites, then Ndb followed by an IRES-EGFP. Cre mediated excision of the floxed beta-geo construct is expected to result in expression of the Ndb/EGFP cassette. (J:154020)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igs1 Mutation:  10 strains or lines available
References
Original:  J:154020 Ye X, et al., Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell. 2009 Oct 16;139(2):285-98
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory