Tg(FXN)YG22Pook
Transgene Detail

Summary

• Symbol: Tg(FXN)YG22Pook
• Name: transgene insertion YG22, Mark A Pook
• MGI ID: MGI:4412181
• Synonyms: YG22
• Transgene: Tg(FXN)YG22Pook Location: unknown
• Alliance: Tg(FXN)YG22Pook page

Transgene origin

• Strain of Origin: CBA x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(FXN)YG22Pook expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FXN (2395)

  Fxn	(MGI:1096879)

• Mutation details: The transgenic construct consists of a 370kb YAC insert that includes the entire human FXN gene with GAA triplet repeat sequences, and was injected into fertilized CBA X C57BL/6 hybrid fertilized oocytes. Founder line YG22 was generated, showing a reduced transmission rate of 21%, indicating germ-line mosaicism of the transgene, compared to 52% transmission to offspring for founder line YG8. One copy of the FXN gene was detected, and contains a single 190 GAA repeat sequence. (J:91581)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Line YG22 exhibits slightly greater age-related repeat instability than line YG8, with a bias toward repeat expansion.

References

• Original: J:91581 Al-Mahdawi S, et al., GAA repeat instability in Friedreich ataxia YAC transgenic mice. Genomics. 2004 Aug;84(2):301-10
• All: 6 reference(s)