Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 7, Susan Dymecki
• MGI ID: MGI:4412286
• Synonyms: RC:FPtox, RC::PFtox, TeNT mice
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154944
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A CAG promoter drives expression of an EGFP/tetanus toxin light chain (tetX) fusion preceded by a floxed STOP signal and an frt flanked mCherry and STOP signal. Cre mediated removal of the first STOP signal is required for expression of mCherry. Cre and Frt mediated recombination are required to remove both STOP signals to allow for expression of the EGFP/tetX fusion. (J:154944)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:154944 Kim JC, et al., Linking genetically defined neurons to behavior through a broadly applicable silencing allele. Neuron. 2009 Aug 13;63(3):305-15
• All: 11 reference(s)