Mtmr14^tm1Ckq
Targeted Allele Detail

Summary

• Symbol: Mtmr14^tm1Ckq
• Name: myotubularin related protein 14; targeted mutation 1, Cheng-Kui Qu
• MGI ID: MGI:4412297
• Synonyms: MIP^-, MTMR14^-
• Gene: Mtmr14 Location: Chr6:113214804-113258353 bp, + strand Genetic Position: Chr6, 52.74 cM
• Alliance: Mtmr14^tm1Ckq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155068
• Parent Cell Line: D1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 5 were replaced by a neo cassette. The absence of protein expression was confirmed by Western blot analysis on lung, liver, heart, kidney, spleen, and skeletal muscle. (J:155068)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtmr14 Mutation: 38 strains or lines available

References

• Original: J:155068 Shen J, et al., Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis. Nat Cell Biol. 2009 Jun;11(6):769-76
• All: 4 reference(s)