Nkx6-2^{tm1(cre/ERT2)Fsh}
Targeted Allele Detail

Summary

• Symbol: Nkx6-2^{tm1(cre/ERT2)Fsh}
• Name: NK6 homeobox 2; targeted mutation 1, Gordon Fishell
• MGI ID: MGI:4412372
• Synonyms: Nkx6-2^CreER, Nkx6-2^{tm1.1(cre/ERT2)Fsh}
• Gene: Nkx6-2 Location: Chr7:139159292-139162713 bp, - strand Genetic Position: Chr7, 84.57 cM
• Alliance: Nkx6-2^{tm1(cre/ERT2)Fsh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155164
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Nkx6-2^{tm1(cre/ERT2)Fsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nkx6-2 (MGI:1352738)

• Exons 1 and 2 were replaced with a cre/ERT2 fusion and floxed self-excising neo cassette. (J:155164)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx6-2 (mouse) Summary of all recombinase alleles driven by Nkx6-2. Alliance mouse Nkx6-2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nkx6-2 Mutation: 17 strains or lines available

References

• Original: J:155164 Sousa VH, et al., Characterization of Nkx6-2-derived neocortical interneuron lineages. Cereb Cortex. 2009 Jul;19 Suppl 1:i1-10
• All: 2 reference(s)