Hes1^{tm1(cre/ERT2)Lcm}
Targeted Allele Detail

Summary

• Symbol: Hes1^{tm1(cre/ERT2)Lcm}
• Name: hes family bHLH transcription factor 1; targeted mutation 1, L Charles Murtaugh
• MGI ID: MGI:4412375
• Synonyms: Hes1^C2, Hes1^CF, Hes1^CreERT2
• Gene: Hes1 Location: Chr16:29883259-29886614 bp, + strand Genetic Position: Chr16, 21.09 cM
• Alliance: Hes1^{tm1(cre/ERT2)Lcm} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154982
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Hes1^{tm1(cre/ERT2)Lcm} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hes1 (MGI:104853)

• Mutation details: A targeting vector generated by bacterial recombineering replaced most of the Hes1 open reading from with a cre/ERT2 sequence linked to an Frt-flanked neomycin resistance cassette. Following homologous recombination in R1 ES cells, germline chimeras were generated and subsequently the neo cassette was excised in vivo by crossing mutants to Gt(ROSA)26Sor^tm1(FLP1)Dym mice. (J:154982, J:169830)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hes1 (mouse) Summary of all recombinase alleles driven by Hes1. Comparative matrix view of recombinase activities Alliance mouse Hes1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hes1 Mutation: 23 strains or lines available

References

• Original: J:154982 Yun S, et al., Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development. 2009 Dec;136(23):3895-906
• All: 10 reference(s)