Grik4^tm1.1Sfh
Targeted Allele Detail

Summary

• Symbol: Grik4^tm1.1Sfh
• Name: glutamate receptor, ionotropic, kainate 4; targeted mutation 1.1, Stephen F Heinemann
• MGI ID: MGI:4413475
• Synonyms: GluK4^-
• Gene: Grik4 Location: Chr9:42431708-42856296 bp, - strand Genetic Position: Chr9, 23.8 cM
• Alliance: Grik4^tm1.1Sfh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155003
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 14 and a floxed neo cassette was inserted downstream of exon 14. Cre mediated recombination removed exon 14. The absence of protein expression was confirmed by western blot analysis on hippocampus extracts. (J:155003)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grik4 Mutation: 48 strains or lines available

References

• Original: J:155003 Fernandes HB, et al., High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling. Neuron. 2009 Sep 24;63(6):818-29
• All: 5 reference(s)