Tspan12^tm1Wye
Targeted Allele Detail

Summary

• Symbol: Tspan12^tm1Wye
• Name: tetraspanin 12; targeted mutation 1, Weilan Ye
• MGI ID: MGI:4414643
• Gene: Tspan12 Location: Chr6:21771394-21852514 bp, - strand Genetic Position: Chr6, 8.73 cM
• Alliance: Tspan12^tm1Wye page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154863
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The translation initiation site and a major portion of the first transmembrane spanning domain of exon 3 were replaced with a IRES, beta-geo, and puro cassette. The absence of protein expression was confirmed by western blot analysis on embryo extracts. (J:154863)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tspan12 Mutation: 26 strains or lines available

References

• Original: J:154863 Junge HJ, et al., TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling. Cell. 2009 Oct 16;139(2):299-311
• All: 4 reference(s)