Ndp^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Ndp^tm1Lex
• Name: Norrie disease (pseudoglioma) (human); targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:4414644
• Synonyms: Norrin^-
• Gene: Ndp Location: ChrX:16751760-16778013 bp, - strand Genetic Position: ChrX, 12.07 cM
• Alliance: Ndp^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154863
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which contained the translation initiation site, was replaced with a IRES, beta-geo, and puro cassette. (J:154863)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndp Mutation: 8 strains or lines available

References

• Original: J:154863 Junge HJ, et al., TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling. Cell. 2009 Oct 16;139(2):299-311
• All: 6 reference(s)