Lrrk2^tm1.1Cai
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm1.1Cai
• Name: leucine-rich repeat kinase 2; targeted mutation 1.1, Huaibin Cai
• MGI ID: MGI:4414662
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm1.1Cai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154755
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and an frt-flanked neo cassette with a second loxP site was inserted into intron 2. Cre mediated recombination removed the neo cassette and exon 2. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:154755)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 159 strains or lines available

References

• Original: J:154755 Parisiadou L, et al., Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. J Neurosci. 2009 Nov 4;29(44):13971-80
• All: 23 reference(s)