Tg(tetO-LRRK2*G2019S)1Cai
Transgene Detail

Summary

• Symbol: Tg(tetO-LRRK2*G2019S)1Cai
• Name: transgene insertion 1, Huaibin Cai
• MGI ID: MGI:4414665
• Transgene: Tg(tetO-LRRK2*G2019S)1Cai Location: unknown
• Alliance: Tg(tetO-LRRK2*G2019S)1Cai page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-LRRK2*G2019S)1Cai expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: The tet operator drives expression of the human cDNA with nucleotide substitutions that result in the amino acid substitution of serine for glycine at position 2019 (G2019S). This mutation is commonly observed in patients with Parkinson's disease and is thought to increase the kinase activity of the protein. No line information given. (J:154755)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:154755 Parisiadou L, et al., Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. J Neurosci. 2009 Nov 4;29(44):13971-80
• All: 1 reference(s)