Gt(ROSA)26Sor^{tm2(Gli2*)Flng}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(Gli2*)Flng}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Fanxin Long
• MGI ID: MGI:4414671
• Synonyms: Rosa26-deltaNGli2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(Gli2*)Flng} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154905
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(Gli2*)Flng} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gli2 (MGI:95728)

• Mutation details: A construct containing a floxed neo cassette with 3 polyadenylation sites, Gli2 cDNA lacking the first 280 N-terminal amino acids, an IRES sequence, and EGFP cDNA was inserted into the locus. Cre mediated recombination is required to obtain expression of the Gli2 cDNA and EGFP. (J:154905)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:154905 Joeng KS, et al., The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. Development. 2009 Dec;136(24):4177-85
• All: 2 reference(s)