Cd79a^{tm2(cre/Esr1*)Reth}
Targeted Allele Detail

Summary

• Symbol: Cd79a^{tm2(cre/Esr1*)Reth}
• Name: CD79A antigen (immunoglobulin-associated alpha); targeted mutation 2, Michael Reth
• MGI ID: MGI:4414764
• Synonyms: mb1-MerCreMEr
• Gene: Cd79a Location: Chr7:24596922-24601283 bp, + strand Genetic Position: Chr7, 13.49 cM
• Alliance: Cd79a^{tm2(cre/Esr1*)Reth} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155473
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Cd79a^{tm2(cre/Esr1*)Reth} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd79a (MGI:101774)

• Mutation details: The MerCreMer construct, which contains two mutated mouse estrogen receptors flanking the cre coding region, was knocked into the locus. This construct sequesters the cre fusion in the cytoplasm until estrogen or a derivative is administered. (J:155473)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd79a (mouse) Summary of all recombinase alleles driven by Cd79a. Alliance mouse Cd79a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd79a Mutation: 24 strains or lines available

References

• Original: J:155473 Duber S, et al., Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells. Blood. 2009 Dec 3;114(24):4960-7
• All: 2 reference(s)