Tg(Ela-KRAS*G12D)9Eps
Transgene Detail

Summary

• Symbol: Tg(Ela-KRAS*G12D)9Eps
• Name: transgene insertion 9, Eric P Sandgren
• MGI ID: MGI:4414765
• Synonyms: EL-KRAS, TgN(Ela1KRAS^G12D)9EPS
• Transgene: Tg(Ela-KRAS*G12D)9Eps Location: unknown Genetic Position: ChrY, Syntenic
• Alliance: Tg(Ela-KRAS*G12D)9Eps page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ela-KRAS*G12D)9Eps expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KRAS (3845)

  Kras	(MGI:96680)

  Transgene codes for a protein with a glycine to aspartic acid mutation.

• Mutation details: A genomic clone encoding human Kras-G12D, exons 1-4 was expressed in pancreatic ductal epithelial cells under the control of the 200-bp Ela enhancer/promoter. (J:83055)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:83055 Grippo PJ, et al., Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant kras in transgenic mice. Cancer Res. 2003 May 1;63(9):2016-9
• All: 10 reference(s)