Cldn7^tm1Yche
Targeted Allele Detail

Summary

• Symbol: Cldn7^tm1Yche
• Name: claudin 7; targeted mutation 1, Yan-Hua Chen
• MGI ID: MGI:4414771
• Gene: Cldn7 Location: Chr11:69855605-69858711 bp, + strand Genetic Position: Chr11, 42.94 cM, cytoband B4
• Alliance: Cldn7^tm1Yche page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155363
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neo cassette. The absence of protein expression was confirmed by immunohistochemistry on kidney samples and western blot analysis. (J:155363)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn7 Mutation: 12 strains or lines available

References

• Original: J:155363 Tatum R, et al., Renal salt wasting and chronic dehydration in claudin-7-deficient mice. Am J Physiol Renal Physiol. 2010 Jan;298(1):F24-34
• All: 2 reference(s)