Plec/Parp10^tm1.1Gwi
Targeted Allele Detail

Summary

• Symbol: Plec/Parp10^tm1.1Gwi
• Name: plectin; targeted mutation 1.1, Gerhard Wiche
• MGI ID: MGI:4414773
• Synonyms: P1c-
• Gene: Plec Location: Chr15:76055174-76115578 bp, - strand Genetic Position: Chr15, 35.48 cM
• Alliance: Plec/Parp10^tm1.1Gwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155511
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intergenic deletion Mutation details: Exons -1, 0, 0a, and 1c of Plec and exons 10 and 11 of Parp10 were replaced with a floxed neo cassette. The neo cassette was removed by cre mediated recombination. The absence of Plec protein expression of isoform C was confirmed by western blot analysis on brain and sciatic nerve extracts. (J:155511)

Generation of the Plec/Parp10^tm1.1Gwi allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plec Mutation: 174 strains or lines available

References

• Original: J:155511 Fuchs P, et al., Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity. J Biol Chem. 2009 Sep 25;284(39):26502-9
• All: 2 reference(s)