Ndp^tm2Nat
Targeted Allele Detail

Summary

• Symbol: Ndp^tm2Nat
• Name: Norrie disease (pseudoglioma) (human); targeted mutation 2, Jeremy Nathans
• MGI ID: MGI:4414794
• Synonyms: Ndp^-
• Gene: Ndp Location: ChrX:16751760-16778013 bp, - strand Genetic Position: ChrX, 12.07 cM
• Alliance: Ndp^tm2Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154020
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the start codon, and a stop codon followed by a PGK-neomycin resistance cassette was placed in-frame at codon 123, inadvertently truncating the last 11 amino acids. The mutation was created in ((129X1/SvJ x 129S1/Sv)F1-Kitl+) - derived R1/E embryonic stem (ES) cells. (J:154020)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ndp Mutation: 8 strains or lines available

Notes

ES cell line = R1/E.

References

• Original: J:154020 Ye X, et al., Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell. 2009 Oct 16;139(2):285-98
• All: 16 reference(s)