Plekhg5^tm1.1Jbar
Targeted Allele Detail

Summary

• Symbol: Plekhg5^tm1.1Jbar
• Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 5; targeted mutation 1.1, Jay Baraban
• MGI ID: MGI:4414815
• Synonyms: Syx^-
• Gene: Plekhg5 Location: Chr4:152156955-152199857 bp, + strand Genetic Position: Chr4, 82.86 cM
• Alliance: Plekhg5^tm1.1Jbar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155152
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites flank the catalytic domain contained in exons 9-13. Germline cre expression results in excision of the floxed exons 9-13. Western blot analysis indicates the loss of full length protein. However, a truncated protein is present. (J:155152)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plekhg5 Mutation: 98 strains or lines available

References

• Original: J:155152 Garnaas MK, et al., Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo. Circ Res. 2008 Sep 26;103(7):710-6
• All: 3 reference(s)