Syne1^tm1.1Chen
Targeted Allele Detail

Summary

• Symbol: Syne1^tm1.1Chen
• Name: spectrin repeat containing, nuclear envelope 1; targeted mutation 1.1, Ju Chen
• MGI ID: MGI:4414824
• Synonyms: Nesprin 1^-
• Gene: Syne1 Location: Chr10:4970917-5501482 bp, - strand Genetic Position: Chr10, 2.01 cM, cytoband A1
• Alliance: Syne1^tm1.1Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155342
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed the sixteenth from last exon and neo cassette. The absence of protein expression was confirmed by western blot analysis and immunohistochemistry on muscle. (J:155342)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syne1 Mutation: 202 strains or lines available

References

• Original: J:155342 Zhang J, et al., Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet. 2010 Jan 15;19(2):329-41
• All: 2 reference(s)