Elavl1^tm1.1Thla
Targeted Allele Detail

Summary

• Symbol: Elavl1^tm1.1Thla
• Name: ELAV like RNA binding protein 1; targeted mutation 1.1, Timothy Hla
• MGI ID: MGI:4414854
• Gene: Elavl1 Location: Chr8:4335382-4375413 bp, - strand Genetic Position: Chr8, 2.0 cM
• Alliance: Elavl1^tm1.1Thla page

Elavl1^tm1.1Thla/Elavl1⁺ mice have increased sensitivity to whole-body irradiation

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155109
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2 through 5 were removed by cre mediated recombination. (J:155109)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elavl1 Mutation: 43 strains or lines available

References

• Original: J:155109 Ghosh M, et al., Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest. 2009 Dec;119(12):3530-43
• All: 1 reference(s)