Gabrg2^tm1.1Stmo
Targeted Allele Detail

Summary

• Symbol: Gabrg2^tm1.1Stmo
• Name: gamma-aminobutyric acid type A receptor, subunit gamma 2; targeted mutation 1.1, Stephen J Moss
• MGI ID: MGI:4415057
• Synonyms: GABAAR gamma2^Y365/7F
• Gene: Gabrg2 Location: Chr11:41801030-41891684 bp, - strand Genetic Position: Chr11, 24.8 cM
• Alliance: Gabrg2^tm1.1Stmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154745
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted Mutations: Insertion, Nucleotide substitutions Mutation details: Nucleotide substitutions result in the amino acid substitutions of two tyrosines with phenylalanine at positions 365 and 367. A floxed neo cassette was inserted between exon 9 and 10 then removed by cre mediated recombination. (J:154745)

Generation of the Gabrg2^tm1.1Stmo allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabrg2 Mutation: 41 strains or lines available

References

• Original: J:154745 Tretter V, et al., Deficits in spatial memory correlate with modified {gamma}-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20039-44
• All: 4 reference(s)