Cdx2^tm1.1Lhn
Targeted Allele Detail

Summary

• Symbol: Cdx2^tm1.1Lhn
• Name: caudal type homeobox 2; targeted mutation 1.1, David Lohnes
• MGI ID: MGI:4415130
• Synonyms: Cdx2^f
• Gene: Cdx2 Location: Chr5:147237710-147244059 bp, - strand Genetic Position: Chr5, 86.86 cM, cytoband G2-G3
• Alliance: Cdx2^tm1.1Lhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154904
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. Cre mediated recombination removed the neo cassette leaving exon 2 floxed. (J:154904)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdx2^tm1.1Lhn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdx2 Mutation: 22 strains or lines available

References

• Original: J:154904 Savory JG, et al., Cdx2 regulation of posterior development through non-Hox targets. Development. 2009 Dec;136(24):4099-110
• All: 13 reference(s)