Atp2a2^tm1.1Iemr
Targeted Allele Detail

Summary

• Symbol: Atp2a2^tm1.1Iemr
• Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; targeted mutation 1.1, Ole Sejersted
• MGI ID: MGI:4415164
• Synonyms: Atp2a2^tm1.1Kba, Serca^flox
• Gene: Atp2a2 Location: Chr5:122591576-122640288 bp, - strand Genetic Position: Chr5, 62.38 cM, cytoband F
• Alliance: Atp2a2^tm1.1Iemr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155628
• Parent Cell Line: E14.1a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 3. Cre mediated recombination removes the neo cassette leaving exons 2 and 3 floxed. (J:155628)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp2a2 Mutation: 76 strains or lines available

References

• Original: J:155628 Andersson KB, et al., Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models. Cell Calcium. 2009 Sep;46(3):219-25
• All: 19 reference(s)