Tg(Prnp-cre/ERT)28.8Ics
Transgene Detail

Summary

• Symbol: Tg(Prnp-cre/ERT)28.8Ics
• Name: transgene insertion 28.8, Mouse Clinical Institute
• MGI ID: MGI:4415180
• Synonyms: PrpCreER, PrP-Cre-ER^T 28.8, PrP-Cre-ER^T28.8^(tg/0)
• Transgene: Tg(Prnp-cre/ERT)28.8Ics Location: unknown
• Alliance: Tg(Prnp-cre/ERT)28.8Ics page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Prnp-cre/ERT)28.8Ics expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: The mouse prion promoter was used to drive the expression of the tamoxifen-inducible form of a Cre recombinase/estrogen receptor fusion protein. Ten transgenic founder lines (28.1-28.10) that transmitted the transgene were obtained. Lines 28.4, 28.6, and 28.8 were further characterized. (J:81569)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prnp (mouse) Summary of all recombinase alleles driven by Prnp. Comparative matrix view of recombinase activities Alliance mouse Prnp gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:81392 Weber P, et al., Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis. Biol Reprod. 2003 Feb;68(2):553-9
• All: 3 reference(s)