Tg(S100A8-cre,-EGFP)1Ilw
Transgene Detail

Summary

• Symbol: Tg(S100A8-cre,-EGFP)1Ilw
• Name: transgene insertion 1, Irving L Weissman
• MGI ID: MGI:4415239
• Synonyms: MRP8-Cre-ires/GFP, Mrp8cre^Tg, Tg(S100A8-cre,-GFP)1Empa, Tg(S100A8-cre,-GFP)1Ilw
• Transgene: Tg(S100A8-cre,-EGFP)1Ilw Location: unknown Genetic Position: Chr5, Syntenic
• Alliance: Tg(S100A8-cre,-EGFP)1Ilw page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutations: Insertion, Intergenic deletion
• Tg(S100A8-cre,-EGFP)1Ilw involves 2 genes/genome features (Ap1s1, Serpine1) View all
• Tg(S100A8-cre,-EGFP)1Ilw expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  S100A8 (6279)

  S100a8

  (MGI:88244)

• Mutation details: The human promoter drives expression of cre followed by an IRES sequence and EGFP in granulocytes and a fraction of myelomonocytic progenitors. Two founders were generated (no line information given). a A single copy of the transgene integrated at a single site on chromosome 5 (137,042,580-137,086,690; mouse mm10). This insertion leads to a 44 kb deletion of the host genome, resulting in complete deletion of the Serpine1 gene and partial deletion of the Ap1s1 gene. (J:94778, J:323640)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	S100A8 (human) Summary of all recombinase alleles driven by S100A8. Alliance human S100A8 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:94778 Passegue E, et al., JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell. 2004 Oct 29;119(3):431-43
• All: 113 reference(s)