Syk^tm1.2Tara
Targeted Allele Detail

Summary

• Symbol: Syk^tm1.2Tara
• Name: spleen tyrosine kinase; targeted mutation 1.2, Alexander Tarakhovsky
• MGI ID: MGI:4415245
• Synonyms: Syk^fl
• Gene: Syk Location: Chr13:52737209-52802828 bp, + strand Genetic Position: Chr13, 27.41 cM, cytoband B-C2
• Alliance: Syk^tm1.2Tara page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115080
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Cre mediated recombination removed the neo cassette leaving exon 1 floxed. (J:115080)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syk Mutation: 42 strains or lines available

References

• Original: J:115080 Saijo K, et al., Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol. 2003 Mar;4(3):274-9
• All: 55 reference(s)