Ate1^tm2.1Avar
Targeted Allele Detail

Summary

• Symbol: Ate1^tm2.1Avar
• Name: arginyltransferase 1; targeted mutation 2.1, Alexander Varshavsky
• MGI ID: MGI:4415248
• Synonyms: Ate1^flox
• Gene: Ate1 Location: Chr7:129993223-130122099 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Ate1^tm2.1Avar page

Small and lean phenotype of Ate1^tm1Avar/Ate1^tm2.1Avar Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155421
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted 300 bp upstream of exon 2 and a floxed hygromycin (Hph) antibiotic-resistance marker was inserted 50 bp downstream of exon 4. Cre mediated recombination removed the Hph cassette leaving exons 2 through 4 floxed. (J:155421)

Generation of the Ate1^tm2.1Avar allele

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ate1 Mutation: 43 strains or lines available

References

• Original: J:155421 Brower CS, et al., Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations. PLoS One. 2009;4(11):e7757
• All: 2 reference(s)