Nefm^tm1Dwc
Targeted Allele Detail

Summary

• Symbol: Nefm^tm1Dwc
• Name: neurofilament, medium polypeptide; targeted mutation 1, Don W Cleveland
• MGI ID: MGI:4415254
• Synonyms: NF-M^S-A
• Gene: Nefm Location: Chr14:68356994-68362453 bp, - strand Genetic Position: Chr14, 35.46 cM
• Alliance: Nefm^tm1Dwc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155659
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: All the codons corresponding to the serines in the lysine-serine-proline (KSP) repeats in exon 3 were modified to code for alanines. An Nefl 3' region and neo cassette were added downstream of exon 3. (J:155659)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nefm Mutation: 28 strains or lines available

References

• Original: J:155659 Garcia ML, et al., Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth. J Neurosci. 2009 Feb 4;29(5):1277-84
• All: 1 reference(s)