Nr1h3^tm1Wexi
Targeted Allele Detail

Summary

• Symbol: Nr1h3^tm1Wexi
• Name: nuclear receptor subfamily 1, group H, member 3; targeted mutation 1, Wen Xie
• MGI ID: MGI:4415263
• Synonyms: LXR-KI, VP-LXRalpha
• Gene: Nr1h3 Location: Chr2:91014406-91033179 bp, - strand Genetic Position: Chr2, 50.52 cM
• Alliance: Nr1h3^tm1Wexi page

Resistance to LPS-induced lung injury in Nr1h3^tm1Wexi/Nr1h3^tm1Wexi mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155709
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Constitutively active) Mutations: Insertion, Intragenic deletion Mutation details: Sequence spanning part of exon 2 through 7 was replaced with a cDNA fused to VP16 activation domain and followed by an SV40 polyadenylation site and neo cassette. This fusion is predicted to create a constitutively active form. (J:155709)

Generation of the Nr1h3^tm1Wexi allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1h3 Mutation: 32 strains or lines available

References

• Original: J:155709 Gong H, et al., Activation of the liver X receptor prevents lipopolysaccharide-induced lung injury. J Biol Chem. 2009 Oct 30;284(44):30113-21
• All: 2 reference(s)