Cacna1a^tm1Nobs
Targeted Allele Detail

Summary

• Symbol: Cacna1a^tm1Nobs
• Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 1, Noboru Suzuki
• MGI ID: MGI:4415271
• Gene: Cacna1a Location: Chr8:85065268-85366875 bp, + strand Genetic Position: Chr8, 40.95 cM
• Alliance: Cacna1a^tm1Nobs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155607
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 1 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:155607, J:155724)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1a Mutation: 118 strains or lines available

References

• Original: J:155724 Kulik A, et al., Immunocytochemical localization of the alpha 1A subunit of the P/Q-type calcium channel in the rat cerebellum. Eur J Neurosci. 2004 Apr;19(8):2169-78
• All: 3 reference(s)