Cacna1a^tm2Nobs
Targeted Allele Detail

Summary

• Symbol: Cacna1a^tm2Nobs
• Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 2, Noboru Suzuki
• MGI ID: MGI:4415272
• Gene: Cacna1a Location: Chr8:85065268-85366875 bp, + strand Genetic Position: Chr8, 40.95 cM
• Alliance: Cacna1a^tm2Nobs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155607
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the translation initiation site and a floxed neo cassette followed by a lacZ gene with nuclear localization sequence was inserted downstream of exon 1. Reduced transcript expression was confirmed by northern blot analysis. (J:155607)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1a Mutation: 118 strains or lines available

References

• Original: J:155607 Saito H, et al., Knockdown of Cav2.1 calcium channels is sufficient to induce neurological disorders observed in natural occurring Cacna1a mutants in mice. Biochem Biophys Res Commun. 2009 Dec 18;390(3):1029-33
• All: 1 reference(s)