Lgmn^tm1Cptr
Targeted Allele Detail

Summary

• Symbol: Lgmn^tm1Cptr
• Name: legumain; targeted mutation 1, Christoph Peters
• MGI ID: MGI:4415342
• Synonyms: AEP^-
• Gene: Lgmn Location: Chr12:102360341-102405987 bp, - strand Genetic Position: Chr12, 51.45 cM
• Alliance: Lgmn^tm1Cptr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155339
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced by a neomycin cassette via homologous recombination. Absence of expression was verified by RT-PCR, western blot and protease activity using a specific fluorescent substrate. (J:155339)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgmn Mutation: 35 strains or lines available

References

• Original: J:155339 Sepulveda FE, et al., Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells. Immunity. 2009 Nov 20;31(5):737-48
• All: 7 reference(s)