Cavin2^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Cavin2^{tm1(KOMP)Vlcg}
• Name: caveolae associated 2; targeted mutation 1, Velocigene
• MGI ID: MGI:4415387
• Gene: Cavin2 Location: Chr1:51328285-51342119 bp, + strand Genetic Position: Chr1, 26.13 cM
• Alliance: Cavin2^{tm1(KOMP)Vlcg} page
• IMPC: Cavin2 gene page

Mutation origin

• Mutant Cell Lines: 11065A-A12, 11065A-B1, 11065A-C2, 11065A-H7
• Germline Transmission: Earliest citation of germline transmission: J:205741
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 12123bp between positions 51328548-51340670 of Chromosome 1 (Build GRCm39). The cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in the lung, heart, fat, skeletal muscle, brain and liver. (J:136110, J:205741)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Cavin2 Mutation: 21 strains or lines available

Notes

Cell line 11065A-H7 was successfully used to make chimeric mice. Germline transmission was accomplished. J:205741

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 2 reference(s)