Parp11tm1(KOMP)Vlcg
Targeted Allele Detail
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Symbol: |
Parp11tm1(KOMP)Vlcg |
Name: |
poly (ADP-ribose) polymerase family, member 11; targeted mutation 1, Velocigene |
MGI ID: |
MGI:4415414 |
Synonyms: |
Parp11- |
Gene: |
Parp11 Location: Chr6:127423803-127471224 bp, + strand Genetic Position: Chr6, 62.39 cM
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Alliance: |
Parp11tm1(KOMP)Vlcg page
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IMPC: |
Parp11 gene page |
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Mutant Cell Lines: |
12032A-A10, 12032A-B7, 12032A-D4, 12032A-F12 |
Germline Transmission: |
Earliest citation of germline transmission:
J:204812
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Parent Cell Line: |
VGB6 (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Project Collection: |
KOMP-Regeneron
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
Vector: ZEN-Ub1
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Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 21037bp between positions 127447671-127468707 of Chromosome 6 (Build GRCm39). This insertion results in the removal of coding exons 4-8 and allows expression of the reporter gene beta-galactosidase under the control of the endogenous promoter. Semi-quantitative RT-PCR analysis of total RNA confirmed the absence of transcripts in kidney, brain, lung and testis tissues from homozygous mutant mice.
(J:136110, J:221906)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: C57BL/6NTac | 12032A-B7 |
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Phenotypes: |
Affected Systems |
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cellular
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√
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teratozoospermia
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√
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abnormal sperm head morphology
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√
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abnormal sperm nucleus morphology
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√
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abnormal spermatid morphology
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√
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reproductive system
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√
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reproductive system phenotype
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N
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teratozoospermia
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√
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abnormal sperm head morphology
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√
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abnormal sperm nucleus morphology
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√
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abnormal spermatid morphology
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√
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abnormal spermiogenesis
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√
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male infertility
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√
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reduced male fertility
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√
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decreased fertilization frequency
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008; |
All: |
5 reference(s) |
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