Dnai1^tm1.1Leo
Targeted Allele Detail

Summary

• Symbol: Dnai1^tm1.1Leo
• Name: dynein axonemal intermediate chain 1; targeted mutation 1.1, Lawrence E Ostrowski
• MGI ID: MGI:4415595
• Synonyms: Dnaic^flox
• Gene: Dnai1 Location: Chr4:41569775-41638158 bp, + strand Genetic Position: Chr4, 21.75 cM
• Alliance: Dnai1^tm1.1Leo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155730
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 17 and 18 were floxed. The frt flanked neo cassette used for selection purposes was removed by flp mediated recombination leaving a single frt site. (J:155730)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnai1 Mutation: 47 strains or lines available

References

• Original: J:155730 Ostrowski LE, et al., Conditional deletion of dnaic1 in a murine model of primary ciliary dyskinesia causes chronic rhinosinusitis. Am J Respir Cell Mol Biol. 2010 Jul;43(1):55-63
• All: 3 reference(s)