Tg(Prnp-ITM2B*)1Ruvi
Transgene Detail

Summary

• Symbol: Tg(Prnp-ITM2B*)1Ruvi
• Name: transgene insertion 1, Ruben Vidal
• MGI ID: MGI:4415606
• Synonyms: Tg-FDD
• Transgene: Tg(Prnp-ITM2B*)1Ruvi Location: unknown
• Alliance: Tg(Prnp-ITM2B*)1Ruvi page

Transgene origin

• Strain of Origin: C3HeB/FeJ

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-ITM2B*)1Ruvi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ITM2B (9445)

  Itm2b

  (MGI:1309517)

  The gene encodes the Danish allele

• Mutation details: This transgene expresses the Danish allele of ITM2B, which includes a 10-nucleotide duplication (795-796InsTTTAATTTGT) in ITM2B, driven by the mouse Prnp promoter. (J:155720)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:155720 Vidal R, et al., Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2. Brain Pathol. 2009 Jan;19(1):58-68
• All: 6 reference(s)