Nrdc^tm1Eiin
Targeted Allele Detail

Summary

• Symbol: Nrdc^tm1Eiin
• Name: nardilysin convertase; targeted mutation 1, Eiichiro Nishi
• MGI ID: MGI:4415719
• Gene: Nrdc Location: Chr4:108857852-108918974 bp, + strand Genetic Position: Chr4, 50.77 cM
• Alliance: Nrdc^tm1Eiin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155532
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 1 was replaced with a floxed cassette containing a lacZ and frt flanked neo gene followed by a polyadenylation sequence. The absence of protein expression was confirmed by western blot analysis and immunohistochemistry. (J:155532)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrdc Mutation: 35 strains or lines available

References

• Original: J:155532 Ohno M, et al., Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nat Neurosci. 2009 Dec;12(12):1506-13
• All: 7 reference(s)