Tnfrsf11a^tm1.1Pngr
Targeted Allele Detail

Summary

• Symbol: Tnfrsf11a^tm1.1Pngr
• Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1.1, Josef M Penninger
• MGI ID: MGI:4415800
• Synonyms: rank^floxed
• Gene: Tnfrsf11a Location: Chr1:105708443-105775709 bp, + strand Genetic Position: Chr1, 49.7 cM
• Alliance: Tnfrsf11a^tm1.1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155398
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt and loxP flanked neo cassette was inserted upstream of exon 2 and an additional loxP was inserted downstream of exon 3. Flp mediated recombination removed the neo cassette leaving exons 2 and 3 floxed. (J:155398)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf11a Mutation: 42 strains or lines available

References

• Original: J:155398 Hanada R, et al., Central control of fever and female body temperature by RANKL/RANK. Nature. 2009 Nov 26;462(7272):505-9
• All: 17 reference(s)